Ethosuximide for preventing seizures
This leaflet is for parents and carers about how to use this medicine in children. Our information may differ from that provided by the manufacturers, because their information usually relates to adults. Read this leaflet carefully. Keep it somewhere safe so that you can read it again.
Do not stop giving Ethosuximide suddenly, as your child may have more seizures.
Name of medicine
Brand names: Zarontin, Emeside
Why is it important for my child to take Ethosuximide?
It is important that your child takes ethosuximide regularly so that they have fewer seizures. Seizures may be also called convulsions or fits.
What is Ethosuximide available as?
- Capsules: 250 mg
- Liquid medicine: 250 mg in 5 mL
When should I give Ethosuximide
- Ethosuximide is usually given twice each day, once in the morning and once in the evening. Ideally, these times are 10–12 hours apart, for example some time between 7 and 8 am, and between 7 and 8 pm.
- Very occasionally Ethosuximide can be given three times a day. This should be in the morning, early afternoon and at bedtime. Ideally, these times are at least 6 hours apart, for example 8 am, 2 pm and 8 pm.
- Give the medicine at about the same time(s) each day so that this becomes part of your child’s daily routine, which will help you to remember.
How much should I give?
Your doctor will work out the amount of Ethosuximide (the dose) that is right for your child. The dose will be shown on the medicine label.
Your doctor may suggest that your child starts with a low dose. They may then increase the dose as your child gets used to the medicine and depending on how they respond to it. Your doctor will explain what to do. If you are not sure how much to give, check with your doctor, nurse or pharmacist.
It is important that you follow your doctor’s instructions about how much to give.
How should I give Ethosuximide?
- Capsules should be swallowed with a glass of water, squash or juice. Your child should not chew the capsule.
- Shake the medicine well. Measure out the right amount using an oral syringe or a medicine spoon. You can get these from your pharmacist. Do not use a kitchen teaspoon as it will not give the right amount.
When should the medicine start working?
It may take a few weeks for Ethosuximide to work properly, so your child may still have seizures during this time. This is because the amount of medicine has to be increased slowly. Continue to give the medicine in the way that you have been told to by your doctor or epilepsy nurse. Ethosuximide may not stop your child’s seizures completely. If you are worried about whether it is helping, contact your doctor but continue to give the medicine.
What if my child is sick (vomits)?
- If your child is sick less than 30 minutes after having a dose of Ethosuximide, give them the same dose again.
- If your child is sick more than 30 minutes after having a dose of Ethosuximide, do not give them another dose. Wait until the next normal dose.
If your child is sick again, seek advice from your family doctor, nurse, pharmacist, or hospital. They will decide what to do based on your child’s condition and the specific medicine involved.
What if I forget to give it?
If you usually give it twice a day: If you remember up to 4 hours after you should have given a dose, give your child the missed dose. For example, if you usually give a dose at about 7am, you can give the missed dose at any time up to 11am. If you remember after that time, do not give the missed dose. Give the next dose as usual.
If you usually give it three times a day: Do not give the missed dose. Just give the next dose as usual.
Never give a double dose of Ethosuximide.
What if I give too much?
You are unlikely to cause harm if you give an extra dose of Ethosuximide by mistake. If you are concerned that you may have given too much, contact your doctor or local NHS services (details at end of leaflet). Have the medicine or packaging with you if you telephone for advice.
Are there any possible side effects?
We use medicines to make our children better, but sometimes they have other effects that we don’t want (side effects).
Side effects you must do something about
If your child is more short of breath or is wheezing more than usual, or their face, lips or tongue start to swell, or they develop a rash, they may be allergic to Ethosuximide. Take your child to hospital or call an ambulance straight away.
If your child starts to have more fits than usual, contact your doctor or take them to hospital straight away.
If your child develops a fever (temperature above 38.°C), sore throat, mouth ulcers, bruising or bleeding, contact your doctor or take them to hospital straight away.
There may sometimes be other side effects that are not listed above. If you notice anything unusual and are concerned, contact your doctor. You can report any suspected side effects to a UK safety scheme at www.mhra.gov.uk/yellowcard
Can other medicines be given at the same time as Ethosuximide?
- You can give your child medicines that contain paracetamol or ibuprofen, unless your doctor has told you not to.
- Ethosuximide should not be taken with some medicines. Tell your doctor or pharmacist about any other medicines your child is taking before giving Ethosuximide.
- Check with your doctor or pharmacist before giving any other medicines to your child. This includes herbal and complementary medicines.
Epilepsy and pregnancy
- Pregnancy presents a risk to both the mother with epilepsy and her unborn baby. If your daughter has sex, it is essential that she uses adequate contraception to prevent an unplanned pregnancy.
- If your daughter thinks she may be pregnant, she should see her doctor as soon as possible but continue taking her medication in the meantime.
Ethosuxamide and pregnancy
- The risk of Ethosuximide causing harm to an unborn baby is low but your daughter must speak to her doctor before trying to conceive
- The oral contraeptive pill can be used safely by women or girls who are taking Ethosuximide.
Is there anything else I need to know about this medicine?
Do not suddenly stop giving Ethosuximide to your child, as they may have a seizure. If you are worried, contact your doctor but carry on giving the medicine to your child as usual.
If your child seems to have more seizures than usual, contact your doctor or epilepsy nurse.
General advice about medicines
Advice about medicines for seizures
- If your doctor decides to stop a particular medicine, they will discuss this with you. They will usually reduce the dose bit by bit.
- It is best that your child always has the same brand of each medicine, as there may be differences between brands. Keep a record of which medicines your child has.
- Try to give medicines at about the same times each day, to help you remember.
- Only give this medicine to your child. Never give it to anyone else, even if their condition appears to be the same, as this could do harm.
- Make sure that you always have enough medicine. Order a new prescription at least 2 weeks before you will run out.
- Make sure that the medicines you have at home have not reached the ‘best before’ or ‘use by’ date on the packaging. Give old medicines to your pharmacist to dispose of.
Do not change the dose of any medicine without talking to your doctor first.
If you think someone else may have taken the medicine by accident, contact your doctor straight away.
Where should I keep this medicine?
- Keep the medicine in a cupboard, away from heat and direct sunlight.
- It does not need to be kept in the fridge.
- Make sure that children cannot see or reach the medicine.
- Keep the medicine in the container it came in.
Who to contact for more information?
Your child’s doctor, pharmacist or nurse will be able to give you more information about Ethosuximide and about other medicines used to treat epilepsy.
England: NHS 111
Scotland: NHS 24
Northern Ireland: NI Direct
Wales: NHS Direct
Tel 111 (free) or 0845 46 47 (2p per minute)111.wales.nhs.uk/
0808 800 5050www.epilepsy.org.uk
01494 601 400epilepsysociety.org.uk
Version . © NPPG, RCPCH and WellChild, all rights reserved. Review by March 2023.
The primary source for the information in this leaflet is the British National Formulary for Children. For details on any other sources used for this leaflet, please contact us through our website, www.medicinesforchildren.org.uk.
We take great care to make sure that the information in this leaflet is correct and up-to-date. However, medicines can be used in different ways for different patients. It is important that you ask the advice of your doctor or pharmacist if you are not sure about something. This leaflet is about the use of these medicines in the UK, and may not apply to other countries. The Royal College of Paediatrics and Child Health (RCPCH), the Neonatal and Paediatric Pharmacists Group (NPPG), WellChild and the contributors and editors cannot be held responsible for the accuracy of information, omissions of information, or any actions that may be taken as a consequence of reading this leaflet.